Acantholysis
Acantholysis is a feature seen in the epidermis as an isolated feature in some skin cancers including solar ks, SCCs and even in melanoma.
It is a major finding in Hailey Hailey disease, Darier's disease and in Pemphigus but is also seen to a lesser extent in Grover's disease. Rarely acantholysis is seen in Pityriasis rubra pilaris.
